Nanotechnology in Orthopaedic Surgery

Abstract

Abstract
The potential applications of nanomaterials such as nanoparticles, nanofibers, nanosurfaces, nanocoatings, nanoscaffolds, and nanocomposites are expanding in orthopaedic surgery. In various physical forms, most nanomaterials are able to enhance the cell response selectively for biological tissue integration or increase the strength and wear resistance of current orthopaedic materials. Currently, much of the work of nanotechnology in orthopaedic surgery is occurring in the laboratory setting or in early in vivo testing. Significant basic and translational research and development is needed to realize its full clinical potential. In addition, the biological, manufacturing, economic, and regulatoryissues with respect to nanotechnology need to be addressed moving forward. Critical to the successful implementation of nanotechnology in orthopaedics will be a multidisciplinary effort between industry and medicine.

Keywords
Nanotechnology, orthobiologics, nanomaterials

Disclosure: The authors have no conflicts of interest to declare.
Received: April 6, 2009 Accepted: April 29, 2009
Correspondence: Samir Mehta, MD, Department of Orthopaedic Surgery, Hospital of the University of Pennsylvania, 2 Silverstein, 3400 Spruce Street, Philadelphia, PA 19104. E: samir.mehta@uphs.upenn.edu